NDST3
Function
Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity.
Pathway
Glycan metabolism; heparan sulfate biosynthesis.
Glycan metabolism; heparin biosynthesis.
Sequence Similarities
Belongs to the sulfotransferase 1 family. NDST subfamily.
Tissue Specificity
Expressed in brain, kidney, liver, fetal and adult lung, adult pancreas, placenta, fetal spleen and fetal thymus. Not detected in adult/ fetal heart and skeletal muscle.
Cellular localization
- Golgi apparatus membrane
- Single-pass type II membrane protein
Alternative names
HSST3, UNQ2544/PRO4998, NDST3, Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3, Glucosaminyl N-deacetylase/N-sulfotransferase 3, N-heparan sulfate sulfotransferase 3, NDST-3, hNDST-3, N-HSST 3