NEBL
Function
Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres (PubMed:27733623).
Isoform 2
May play a role in the assembly of focal adhesions.
Tissue Specificity
Abundantly expressed in cardiac muscle, but not in skeletal or smooth muscle. Localized to Z-lines in cardiac cells and to dense bodies in nonmuscle cells. Isoform 2 is expressed in non-muscle cells such as in fibroblasts.
Cellular localization
- Isoform 2
- Cytoplasm
Alternative names
C10orf113, LNEBL, NEBL, Nebulette, Actin-binding Z-disk protein