Adaptin ear-binding coat-associated protein 2

The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is tuned by the acidic context surrounding the motif and the properties of the second residue of the motif itself (By similarity).

Involved in endocytosis.

Belongs to the NECAP family.

• Cytoplasmic vesicle
• Clathrin-coated vesicle membrane
• Cell membrane
• Colocalizes with AP-2 at the plasma membrane.

Adaptin ear-binding coat-associated protein 2, NECAP endocytosis-associated protein 2, NECAP-2, NECAP2

• entrezGene:55707
• omim:611624
• swissprot:Q9NVZ3

Proteins

Oncology

28339Da