NECAP2
Domain
The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is tuned by the acidic context surrounding the motif and the properties of the second residue of the motif itself (By similarity).
Function
Involved in endocytosis.
Sequence Similarities
Belongs to the NECAP family.
Cellular localization
- Cytoplasmic vesicle
- Clathrin-coated vesicle membrane
- Cell membrane
- Colocalizes with AP-2 at the plasma membrane.
Alternative names
Adaptin ear-binding coat-associated protein 2, NECAP endocytosis-associated protein 2, NECAP-2, NECAP2