Nectin-3

Cell adhesion molecule that promotes cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions (PubMed:16216929). Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1 (PubMed:16216929). Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation (PubMed:16216929). Involved in axon guidance by promoting contacts between the commissural axons and the floor plate cells (By similarity). Also involved in the formation of cell-cell junctions, including adherens junctions and synapses (By similarity). Promotes formation of checkerboard-like cellular pattern of hair cells and supporting cells in the auditory epithelium via heterophilic interaction with NECTIN1: NECTIN1 is present in the membrane of hair cells and associates with NECTIN3 on supporting cells, thereby mediating heterotypic adhesion between these two cell types (By similarity). Plays a role in the morphology of the ciliary body (By similarity).

Belongs to the nectin family.

Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines.

• Cell membrane
• Single-pass membrane protein
• Postsynaptic cell membrane
• Single-pass type I membrane protein
• Cell junction
• Adherens junction
• In the auditory epithelium, specificaly localizes to the apical side of the lateral membranes of supporting cells.

CD113, PRR3, PVRL3, NECTIN3, Nectin-3, CDw113, Nectin cell adhesion molecule 3, Poliovirus receptor-related protein 3

• entrezGene:25945
• omim:607147
• swissprot:Q9NQS3

Proteins

Immuno-oncology

61002Da