NECTIN4
Function
Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.
(Microbial infection) Acts as a receptor for measles virus.
Involvement in disease
Ectodermal dysplasia-syndactyly syndrome 1
EDSS1
A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDSS1 is characterized by the association of hair and teeth abnormalities with cutaneous syndactyly of the hands and/or feet. Hair morphologic abnormalities include twists at irregular intervals (pilli torti) and swelling along the shafts, particularly associated with areas of breakage. Dental findings consist of abnormally widely spaced teeth, with peg-shaped and conical crowns. Patients have normal sweating.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
The soluble form is produced by proteolytic cleavage at the cell surface (shedding), probably by ADAM17/TACE.
Sequence Similarities
Belongs to the nectin family.
Tissue Specificity
Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
- Cell junction
- Adherens junction
- Colocalizes with AFDN at cadherin-based adherens junctions (PubMed:11544254).
- Processed poliovirus receptor-related protein 4
- Secreted
- The secreted form is found in breast tumor patients (PubMed:15784625).
Alternative names
LNIR, PRR4, PVRL4, NECTIN4, Nectin-4, Ig superfamily receptor LNIR, Nectin cell adhesion molecule 4, Poliovirus receptor-related protein 4