Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (PubMed:22723690).
There are a number of repeats of the tripeptide K-S-P, NFH is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFH results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber.
Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincidentally with a change in the neurofilament function.
Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization.
Belongs to the intermediate filament family.
Expressed in the sciatic nerve (at protein level).
Proteins
Neuroscience
116994Da
We found 4 products in 2 categories
ab274434
Anti-Neurofilament heavy polypeptide antibody [EPR22806-69] - BSA and Azide free (Detector)
ab253366
Mouse Neurofilament Heavy Polypeptide Antibody Pair - BSA and Azide free (NEFH)