Nefl
Domain
The extra mass and high charge density that distinguish the neurofilament proteins from all other intermediate filament proteins are due to the tailpiece extensions. This region may form a charged scaffolding structure suitable for interaction with other neuronal components or ions.
Function
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity).
Post-translational modifications
O-glycosylated; contains three N-acetylglucosamine side chains.
Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization.
Ubiquitinated in the presence of TRIM2 and UBE2D1.
Sequence Similarities
Belongs to the intermediate filament family.
Tissue Specificity
Expressed in the dorsal root ganglion neurons (at protein level).
Cellular localization
- Cell projection
- Axon
- Cytoplasm
- Cytoskeleton
Alternative names
Nf68, Nfl, Nefl, Neurofilament light polypeptide, NF-L, 68 kDa neurofilament protein, Neurofilament triplet L protein