Nek1
Developmental stage
In female, expressed as follicles enter the secondary stage until ovulation occurs. In the male reproductive system, the expression is limited to spermatocytes and spermatids.
Function
Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:1382974). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:18843199). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (By similarity). May be implicated in the control of meiosis (PubMed:1382974). Involved in cilium assembly (By similarity).
Sequence Similarities
Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
Tissue Specificity
Predominantly in testes (germ cells and Sertoli cells). Lower levels in ovary (oocytes and granulosa cells), thymus and lung.
Cellular localization
- Nucleus
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Centrosome
- Associated with the pericentriolar material (By similarity). Localizes to centrosome during interphase and mitosis (PubMed:16267153).
Alternative names
Serine/threonine-protein kinase Nek1, Never in mitosis A-related kinase 1, NimA-related protein kinase 1, Nek1