NEK11
Developmental stage
Predominantly expressed at S/G2/M phase.
Function
Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation.
Post-translational modifications
Phosphorylated by NEK2. Phosphorylation at Ser-273 is important for its activation.
Sequence Similarities
Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
Tissue Specificity
Poorly expressed in cerebellum, trachea, lung, appendix, and uterus.
Cellular localization
- Nucleus
- Nucleus
- Nucleolus
- Nuclear during interphase but moves to the polar microtubules during prometaphase and metaphase (PubMed:12154088). Accumulates in the nucleolus in G1/S-arrested cells (PubMed:15161910).
Alternative names
Serine/threonine-protein kinase Nek11, Never in mitosis A-related kinase 11, NimA-related protein kinase 11, NEK11