NELFCD
Function
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:12612062). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:10199401).
(Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II.
Sequence Similarities
Belongs to the NELF-D family.
Tissue Specificity
Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal and cardiac muscle, adrenal, thyroid, kidney and pancreas.
Cellular localization
- Nucleus
Alternative names
NELFD, TH1, TH1L, HSPC130, NELFCD, Negative elongation factor C/D, NELF-C/D, TH1-like protein