NEO1
Domain
The Fibronectin repeats 5 and 6 mediate interaction with RGM family molecules.
Function
Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response.
Sequence Similarities
Belongs to the immunoglobulin superfamily. DCC family.
Tissue Specificity
Widely expressed and also in cancer cell lines.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
Alternative names
IGDCC2, NGN, NEO1, Neogenin, Immunoglobulin superfamily DCC subclass member 2