Neo1
Developmental stage
Expressed ubiquitously throughout the mid to late stages of gestation and in adult tissues. Strong expression is observed in the ventral region of the ventricular zone of the 15.5 dpc mouse neural tube, as well as in the ventricular zones of the mesencephalon and rhombencephalon. Isoform 3 and isoform 4 are expressed at higher level compared to other isoforms between 11.5 dpc and 16.5 dpc.
Domain
The Fibronectin repeats 5 and 6 mediate interaction with RGM family molecules.
Function
Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response.
Sequence Similarities
Belongs to the immunoglobulin superfamily. DCC family.
Tissue Specificity
Widely expressed.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
Alternative names
Ngn, Neogenin