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NES

Function

Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division (By similarity). Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells.

Post-translational modifications

Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized (By similarity).

Sequence similarities

Belongs to the intermediate filament family.

Alternative names

  • Nestin
  • Nes

Target type

Proteins

Primary research area

Neuroscience

Molecular weight

207124Da