NES

Upon terminal neural differentiation, nestin is down-regulated and replaced by neurofilaments.

Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity).

Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized (By similarity).

Belongs to the intermediate filament family.

CNS stem cells.

Nbla00170, NES, Nestin

• entrezGene:10763
• omim:600915
• swissprot:P48681

Proteins

Neuroscience

177439Da