Nesprin-3
Domain
The KASH domain is involved in the binding to SUN1 and SUN2 through recognition of their SUN domains.
Function
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells (By similarity).
Post-translational modifications
The disulfid bond with SUN1 or SUN2 is required for stability of the respective LINC complex under tensile forces.
Sequence Similarities
Belongs to the nesprin family.
Tissue Specificity
Ubiquitous.
Cellular localization
- Nucleus outer membrane
- Single-pass type IV membrane protein
- Nucleus envelope
- Rough endoplasmic reticulum
Alternative names
Nesprin-3, KASH domain-containing protein 3, Nuclear envelope spectrin repeat protein 3, KASH3, Syne3