NET1
Function
Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.
Tissue Specificity
Widely expressed.
Cellular localization
- Cytoplasm
- Nucleus
Alternative names
ARHGEF8, NET1, Neuroepithelial cell-transforming gene 1 protein, Proto-oncogene p65 Net1, Rho guanine nucleotide exchange factor 8