NEUROD1
GeneName
NEUROD1
Summary
NEUROD1, also known as beta2 or NeuroD, is a 40kDa transcription factor that plays a vital role in neurogenesis and the differentiation of various cell types, particularly in the pancreas and nervous system. It is localised in the nucleus, cytoplasm, and chromatin, where it functions as a DNA-binding transcription activator specific to RNA polymerase II. NEUROD1 is involved in processes such as amacrine cell differentiation, insulin secretion, and the development of the cerebellum and dentate gyrus. It binds to E-box sequences in DNA and can form heterodimers with other proteins, facilitating its regulatory roles in gene expression.
Importance
NEUROD1 is relevant to: - Neurodevelopmental disorders, as it is essential for proper neuronal differentiation and function - Diabetes research due to its role in insulin secretion and pancreatic cell differentiation - Understanding mechanisms of cell fate determination in the endocrine pancreas - Potential therapeutic targets for neurodegenerative diseases, given its involvement in neurogenesis and neuronal survival
Top Products
For researchers investigating NEUROD1, we highly recommend the top-selling recombinant antibody, Anti-NeuroD1 antibody [EPR20766] (ab213725). This antibody has been validated for use in a variety of applications, including immunohistochemistry (IHC), western blotting (WB), flow cytometry (FC), and immunoprecipitation (IP), making it a versatile tool for your research needs. With 37 citations, it is well-regarded in the scientific community, reflecting its reliability and effectiveness in NEUROD1 detection. This recombinant antibody ensures batch-to-batch consistency, providing confidence in your experimental results.
Abcam Product Citation Summary
The data indicates that NEUROD1 is studied in various contexts, including human duodenal biopsies and mouse duodenum tissue, focusing on protein expression and conditional expression. Additionally, NEUROD1 is investigated in relation to neuronal differentiation in both human and rat models, highlighting its role in diabetes and the effects of electro-acupuncture on neuron differentiation.
Abcam Product Citation Table
Function
Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).
Involvement in disease
Maturity-onset diabetes of the young 6
MODY6
A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
None
The disease is caused by variants affecting the gene represented in this entry.
Type 2 diabetes mellitus
T2D
A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
None
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Post-translational modifications
Phosphorylated. In islet cells, phosphorylated on Ser-274 upon glucose stimulation; which may be required for nuclear localization. In activated neurons, phosphorylated on Ser-335; which promotes dendritic growth. Phosphorylated by MAPK1; phosphorylation regulates heterodimerization and DNA-binding activities. Phosphorylation on Ser-266 and Ser-274 increases transactivation on the insulin promoter in glucose-stimulated insulinoma cells (By similarity).
Cellular localization
- Cytoplasm
- Nucleus
- In pancreatic islet cells, shuttles to the nucleus in response to glucose stimulation (By similarity). Colocalizes with NR0B2 in the nucleus.
Alternative names
BHLHA3, NEUROD, NEUROD1, Neurogenic differentiation factor 1, NeuroD, NeuroD1, Class A basic helix-loop-helix protein 3, bHLHa3