NFAM1
Domain
The ITAM domain displays no close similarity to any existing ITAMs, except for four conserved positions. The phosphorylated ITAM domain binds ZAP70 and SYK.
Function
May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking.
Post-translational modifications
N-glycosylated.
Tissue Specificity
Highly expressed in neutrophils, primary monocytes, mast cells, monocytic cell lines and lymphocytes. Also expressed in spleen B and T-cells, and lung. Expressed at low level in non-immune tissue.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
- Partially recruited to lipid rafts upon BCR stimulation.
Alternative names
CNAIP, NFAM1, NFAT activation molecule 1, Calcineurin/NFAT-activating ITAM-containing protein, NFAT-activating protein with ITAM motif 1