Nfasc
Developmental stage
Strongly but transiently up-regulated in oligodendrocytes at the onset of myelinogenesis. Once these last have engaged their target exons, expression declines precipitously.
Domain
Homophilic adhesion is primarily mediated by the interaction of the second Ig-like domains.
Function
Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions. Isoform 2/isoform 3 may be responsible for mediating and signaling axon-glial interaction during the early stages of myelination.
Post-translational modifications
Isoform 2/isoform 3 is phosphorylated at P12. Dephosphorylation is required for ankyrin binding.
Sequence Similarities
Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
Tissue Specificity
Isoform 1 is expressed at Nodes of Ranvier while isoform 2/isoform 3 is expressed in unmyelinated axons.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
- Isoform 1 colocalizes with ankyrin G at the nodes of Ranvier. Isoform 2/ isoform 3 is a glial component of the paranodal axo-glial junction.
Alternative names
Neurofascin, Nfasc