NFIC

Domain

The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.

Function

Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

Sequence Similarities

Belongs to the CTF/NF-I family.

Cellular localization

• Nucleus

Alternative names

NFI, NFIC, Nuclear factor 1 C-type, NF1-C, Nuclear factor 1/C, CCAAT-box-binding transcription factor, Nuclear factor I/C, TGGCA-binding protein, CTF, NF-I/C, NFI-C

Database links

swissprot:P08651 omim:600728 entrezGene:4782 omim:600729 swissprot:O00712 entrezGene:4781