NFKBIB phospho T19
Function
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
Post-translational modifications
Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation.
Sequence Similarities
Belongs to the NF-kappa-B inhibitor family.
Tissue Specificity
Expressed in all tissues examined.
Cellular localization
- Cytoplasm
- Nucleus
Alternative names
IKBB, TRIP9, NFKBIB, NF-kappa-B inhibitor beta, NF-kappa-BIB, I-kappa-B-beta, Thyroid receptor-interacting protein 9, IkB-B, IkB-beta, IkappaBbeta, TR-interacting protein 9, TRIP-9