NFKBIE
Function
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.
Post-translational modifications
Serine phosphorylated; followed by proteasome-dependent degradation.
Sequence Similarities
Belongs to the NF-kappa-B inhibitor family.
Tissue Specificity
Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages.
Cellular localization
- Cytoplasm
Alternative names
IKBE, NFKBIE, NF-kappa-B inhibitor epsilon, NF-kappa-BIE, I-kappa-B-epsilon, IkB-E, IkB-epsilon, IkappaBepsilon