NFKBIE

Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.

Serine phosphorylated; followed by proteasome-dependent degradation.

Belongs to the NF-kappa-B inhibitor family.

Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages.

• Cytoplasm

IKBE, NFKBIE, NF-kappa-B inhibitor epsilon, NF-kappa-BIE, I-kappa-B-epsilon, IkB-E, IkB-epsilon, IkappaBepsilon

• entrezGene:4794
• omim:604548
• swissprot:O00221

Proteins

Immunology & Infectious Disease

52864Da