nfsB
Function
Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred. Capable of reducing nitrofurazone, quinones and the anti-tumor agent CB1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide). The reduction of CB1954 results in the generation of cytotoxic species.
Sequence Similarities
Belongs to the nitroreductase family.
Alternative names
dprA, nfnB, nfsI, ntr, b0578, JW0567, nfsB, Oxygen-insensitive NAD(P)H nitroreductase, Dihydropteridine reductase, FMN-dependent nitroreductase