NHERF4

Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (PubMed:11950846). Stimulates SLC9A3 activity in the presence of elevated calcium ions (PubMed:19088451).

Phosphorylation at Ser-395 negatively regulates its interaction with SLC26A3.

Expressed in kidney and the gastrointestinal tract. Not detected in brain, heart, skeletal muscle or cells of hematopoietic origin.

• Cell membrane
• Peripheral membrane protein
• Cytoplasm
• Preferentially accumulates at the apical surface and ileal brush border of intestinal epithelial cells (PubMed:11950846, PubMed:19088451).

IKEPP, PDZD3, PDZK2, DLNB27, NHERF4, Na(+)/H(+) exchange regulatory cofactor NHE-RF4, NHERF-4, Intestinal and kidney-enriched PDZ protein, Natrium-phosphate cotransporter IIa C-terminal-associated protein 2, PDZ domain-containing protein 2, PDZ domain-containing protein 3, Sodium-hydrogen exchanger regulatory factor 4, Na/Pi cotransporter C-terminal-associated protein 2, NaPi-Cap2

• entrezGene:79849
• omim:607146
• swissprot:Q86UT5

Proteins

Metabolism

61032Da