NIBAN2

May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro.

Phosphorylated at Ser-641, Ser-646, Ser-692 and Ser-696 by the BRAF/MKK/ERK signaling cascade. In melanoma cells, the C-terminal phosphorylation may prevent targeting to the plasma membrane.

As apoptosis proceeds, degraded via an proteasome-independent pathway, probably by caspases.

Belongs to the Niban family.

• Cytoplasm
• Cytosol
• Cell junction
• Adherens junction
• Membrane
• Lipid-anchor
• In exponentially growing cells, exclusively cytoplasmic. Cell membrane localization is observed when cells reach confluency and during telophase. In melanoma cells, targeting to the plasma membrane may be impaired by C-terminal phosphorylation.

C9orf88, FAM129B, NIBAN2, Protein Niban 2, Meg-3, Melanoma invasion by ERK, Niban-like protein 1, Protein FAM129B, MINERVA

• entrezGene:64855
• swissprot:Q96TA1

Proteins

Oncology

84138Da