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NIBAN2

OverviewProducts

Function

May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro.

Post-translational modifications

Phosphorylated at Ser-641, Ser-646, Ser-692 and Ser-696 by the BRAF/MKK/ERK signaling cascade. In melanoma cells, the C-terminal phosphorylation may prevent targeting to the plasma membrane.

As apoptosis proceeds, degraded via an proteasome-independent pathway, probably by caspases.

Sequence similarities

Belongs to the Niban family.

Cellular localization

  • Cytoplasm
  • Cytosol
  • Cell junction
  • Adherens junction
  • Membrane
  • Lipid-anchor
  • In exponentially growing cells, exclusively cytoplasmic. Cell membrane localization is observed when cells reach confluency and during telophase. In melanoma cells, targeting to the plasma membrane may be impaired by C-terminal phosphorylation.

Alternative names

  • Protein Niban 2
  • Meg-3
  • Melanoma invasion by ERK
  • Niban-like protein 1
  • Protein FAM129B
  • MINERVA
  • FAM129B
  • C9orf88
  • NIBAN2

Database links

Target type

Proteins

Molecular weight

84138Da