NIBAN2
Function
May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro.
Post-translational modifications
Phosphorylated at Ser-641, Ser-646, Ser-692 and Ser-696 by the BRAF/MKK/ERK signaling cascade. In melanoma cells, the C-terminal phosphorylation may prevent targeting to the plasma membrane.
As apoptosis proceeds, degraded via an proteasome-independent pathway, probably by caspases.
Sequence Similarities
Belongs to the Niban family.
Cellular localization
- Cytoplasm
- Cytosol
- Cell junction
- Adherens junction
- Membrane
- Lipid-anchor
- In exponentially growing cells, exclusively cytoplasmic. Cell membrane localization is observed when cells reach confluency and during telophase. In melanoma cells, targeting to the plasma membrane may be impaired by C-terminal phosphorylation.
Alternative names
C9orf88, FAM129B, NIBAN2, Protein Niban 2, Meg-3, Melanoma invasion by ERK, Niban-like protein 1, Protein FAM129B, MINERVA