Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3
Developmental stage
Expressed throughout development and in adulthood.
Function
Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (By similarity). Protects against axonal degeneration following injury.
Pathway
Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.
Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.
Sequence Similarities
Belongs to the eukaryotic NMN adenylyltransferase family.
Cellular localization
- Mitochondrion
Alternative names
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3, NMN/NaMN adenylyltransferase 3, Nicotinamide-nucleotide adenylyltransferase 3, Nicotinate-nucleotide adenylyltransferase 3, NMN adenylyltransferase 3, NaMN adenylyltransferase 3, Nmnat3