NIT2
Function
Has omega-amidase activity (PubMed:19595734, PubMed:22674578). The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively (PubMed:19595734).
Sequence Similarities
Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.
Tissue Specificity
Detected in fetal brain (at protein level). Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, prostate, spleen, thymus, prostate, testis, ovary, small intestine and colon.
Cellular localization
- Cytoplasm
Alternative names
CUA002, NIT2, Omega-amidase NIT2, Nitrilase homolog 2