Skip to main content

Nitric oxide synthase, brain

Domain

The PDZ domain participates in protein-protein interaction, and is responsible for targeting nNos to synaptic membranes. Mediates interaction with VAC14.

Function

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.

Post-translational modifications

Ubiquitinated; mediated by STUB1/CHIP in the presence of Hsp70 and Hsp40 (in vitro).

Sequence similarities

Belongs to the NOS family.

Tissue specificity

Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland.

Cellular localization

  • Cell membrane
  • Sarcolemma
  • Peripheral membrane protein
  • Cell projection
  • Dendritic spine
  • In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex (By similarity). In neurons, enriched in dendritic spines (By similarity).

Alternative names

  • Nitric oxide synthase 1
  • Constitutive NOS
  • NC-NOS
  • NOS type I
  • Neuronal NOS
  • Peptidyl-cysteine S-nitrosylase NOS1
  • N-NOS
  • nNOS
  • bNOS
  • NOS1

Target type

Proteins

Primary research area

Neuroscience

Molecular weight

160970Da

We found 13 products in 3 categories

Primary Antibodies

Assay Kits

Target

Reactive species

Proteins & Peptides

Target

Species of origin

Nature