NK-1R
Function
This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin K.
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
Tac1r, Substance-P receptor, SPR, NK-1 receptor, Tachykinin receptor 1, NK-1R