NKX2-2
Domain
The homeodomain is essential for interaction with OLIG2.
Function
Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity).
Sequence Similarities
Belongs to the NK-2 homeobox family.
Cellular localization
- Nucleus
Alternative names
NKX2.2, NKX2B, NKX2-2, Homeobox protein Nkx-2.2, Homeobox protein NK-2 homolog B