NKX3-1

Function

Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.

Post-translational modifications

Ubiquitinated by TOPORS; monoubiquitinated at several residues and also polyubiquitinated on single residues.

Sequence similarities

Belongs to the NK-3 homeobox family.

Tissue specificity

Highly expressed in the prostate and, at a lower level, in the testis.

Cellular localization

• Nucleus

Alternative names

• Homeobox protein Nkx-3.1
• Homeobox protein NK-3 homolog A
• NKX3.1
• NKX3-1
• NKX3A

Database links

• entrezGene:4824
• omim:602041
• swissprot:Q99801

Target type

Proteins

Molecular weight

26350Da