NKX3-1

Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.

Ubiquitinated by TOPORS; monoubiquitinated at several residues and also polyubiquitinated on single residues.

Belongs to the NK-3 homeobox family.

Highly expressed in the prostate and, at a lower level, in the testis.

• Nucleus

NKX3.1, NKX3A, NKX3-1, Homeobox protein Nkx-3.1, Homeobox protein NK-3 homolog A

• entrezGene:4824
• omim:602041
• swissprot:Q99801

Proteins

Oncology

26350Da