NKX6-1

Domain

The C-terminal domain contributes to sequence-specific DNA-binding.

Function

Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in the development of insulin-producing beta cells in the islets of Langerhans at the secondary transition (By similarity). Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity).

Tissue specificity

Pancreatic beta cells.

Cellular localization

• Nucleus

Alternative names

• Homeobox protein Nkx-6.1
• Homeobox protein NK-6 homolog A
• NKX6-1
• NKX6A

Database links

• entrezGene:4825
• omim:602563
• swissprot:P78426

Target type

Proteins

Molecular weight

37849Da