NLGN4X
Function
Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members.
Involvement in disease
Autism, X-linked 2
AUTSX2
A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate intellectual disability.
None
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the type-B carboxylesterase/lipase family.
Tissue Specificity
Expressed at highest levels in heart. Expressed at lower levels in liver, skeletal muscle and pancreas and at very low levels in brain.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
- Postsynaptic density membrane
Alternative names
KIAA1260, NLGN4, UNQ365/PRO701, NLGN4X, Neuroligin X, HNLX