NME6
Function
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.
Sequence Similarities
Belongs to the NDK family.
Tissue Specificity
Expressed at a moderately low level in many tissues. Most abundant in kidney, prostate, ovary, intestine, and spleen.
Alternative names
Nucleoside diphosphate kinase 6, NDK 6, NDP kinase 6, Inhibitor of p53-induced apoptosis-alpha, nm23-H6, IPIA-alpha, NME6