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NMRK1

Function

Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). The enzyme also phosphorylates the antitumor drugs tiazofurin and 3-deazaguanosine.

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis.

Sequence Similarities

Belongs to the uridine kinase family. NRK subfamily.

Alternative names

C9orf95, NRK1, NMRK1, Nicotinamide riboside kinase 1, NRK 1, NmR-K 1, Nicotinic acid riboside kinase 1, Ribosylnicotinamide kinase 1, Ribosylnicotinic acid kinase 1, RNK 1

swissprot:Q9NWW6 entrezGene:54981 omim:608704