NMRK2
Function
Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis.
Pathway
Cofactor biosynthesis; NAD(+) biosynthesis.
Sequence Similarities
Belongs to the uridine kinase family. NRK subfamily.
Tissue Specificity
Predominantly expressed in skeletal muscle and, at a much lower level, in the heart (at protein level). No expression in brain, kidney, liver, lung, pancreas nor placenta.
Alternative names
ITGB1BP3, NRK2, NMRK2, Nicotinamide riboside kinase 2, NRK 2, NmR-K 2, Integrin beta-1-binding protein 3, Muscle integrin-binding protein, Nicotinic acid riboside kinase 2, Ribosylnicotinamide kinase 2, Ribosylnicotinic acid kinase 2, MIBP, RNK 2