NMT1
Function
Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins (PubMed:22865860, PubMed:25255805, PubMed:32686708, PubMed:34999170, PubMed:9353336, PubMed:9506952). Also able to mediate N-terminal lysine myristoylation of proteins: catalyzes myristoylation of ARF6 on both 'Gly-2' and 'Lys-3' (PubMed:32103017, PubMed:32111831). Lysine myristoylation is required to maintain ARF6 on membranes during the GTPase cycle (PubMed:32103017).
Sequence Similarities
Belongs to the NMT family.
Tissue Specificity
Heart, gut, kidney, liver and placenta.
Cellular localization
- Cytoplasm
- Cytoplasm
- Cytosol
- Membrane
- Peripheral membrane protein
- Copurifies with ribosomes.
Alternative names
NMT, NMT1, Glycylpeptide N-tetradecanoyltransferase 1, Myristoyl-CoA:protein N-myristoyltransferase 1, Peptide N-myristoyltransferase 1, Protein-lysine myristoyltransferase NMT1, HsNMT1, NMT 1, Type I N-myristoyltransferase