NMU
Function
Neuromedin-U-25
Ligand for receptors NMUR1 and NMUR2 (By similarity). Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder.
Neuromedin precursor-related peptide 33
Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36.
Neuromedin precursor-related peptide 36
Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system.
Sequence Similarities
Belongs to the NmU family.
Tissue Specificity
Expressed throughout the enteric nervous system with highest levels being found in the jejunum.
Cellular localization
- Secreted
Alternative names
Neuromedin-U, NMU