NOC2L

Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter.

Belongs to the NOC2 family.

• Nucleus
• Nucleoplasm
• Nucleus
• Nucleolus
• Translocates from the nucleoli to the nucleoplasm in presence of several stressors like ultraviolet irradiation and actinomycin-D. Predominantly detected in the nucleoli in non-mitotic cells. Predominantly detected in nucleoplasma in cells undergoing mitosis.

NIR, NOC2L, Nucleolar complex protein 2 homolog, Protein NOC2 homolog, NOC2-like protein, Novel INHAT repressor

• entrezGene:26155
• omim:610770
• swissprot:Q9Y3T9

Proteins

Epigenetics

84919Da