Nop2
Function
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA. Required for efficient rRNA processing and 60S ribosomal subunit biogenesis. Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes. May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation.
Post-translational modifications
Citrullinated by PADI4.
Sequence Similarities
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
Cellular localization
- Nucleus
- Nucleolus
- Nucleus
- Localizes predominantly in the nucleolus and to a smaller extent in the nucleus.
Alternative names
Nol1, Nop2, 28S rRNA (cytosine-C(5))-methyltransferase, Nucleolar protein 1, Nucleolar protein 2 homolog, Proliferating-cell nucleolar antigen p120, Proliferation-associated nucleolar protein p120