NOP58
Function
Required for 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797).
Post-translational modifications
Sumoylation is essential for high-affinity binding to snoRNAs.
Sequence Similarities
Belongs to the NOP5/NOP56 family.
Tissue Specificity
Ubiquitous.
Cellular localization
- Nucleus
- Nucleolus
- Nucleus
- Nucleoplasm
- Localizes to the nucleolus with a minor part present in the nucleoplasm.
Alternative names
NOL5, NOP5, HSPC120, NOP58, Nucleolar protein 58, Nucleolar protein 5