Nos3

Function

Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. May play a significant role in normal and abnormal limb development.

Post-translational modifications

Phosphorylation by AMPK at Ser-1176 in the presence of Ca(2+)-calmodulin (CaM) activates activity. In absence of Ca(2+)-calmodulin, AMPK also phosphorylates Thr-494, resulting in inhibition of activity (By similarity).

Sequence Similarities

Belongs to the NOS family.

Cellular localization

• Membrane
• Caveola
• Cytoplasm
• Cytoskeleton
• Golgi apparatus
• Cell membrane
• Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle, which is favored by interaction with NOSIP and results in a reduced enzymatic activity.

Alternative names

Ecnos, Nos3, Nitric oxide synthase 3, Constitutive NOS, EC-NOS, NOS type III, cNOS, NOSIII, Endothelial NOS, eNOS

Database links

swissprot:P70313 entrezGene:18127

Other research areas

• Cardiovascular
• Immuno-oncology