NOSIP
Domain
The U-box-like region is a truncated U-box domain. It is unknown whether it is functional or not.
Function
E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (PubMed:11149895, PubMed:15548660, PubMed:16135813).
Sequence Similarities
Belongs to the NOSIP family.
Tissue Specificity
Expressed in heart, brain and lung. Present in endothelial cells (at protein level).
Cellular localization
- Cytoplasm
- Nucleus
- Translocates from nucleus to cytoplasm in the G2 phase of the cell cycle (PubMed:16135813).
Alternative names
CGI-25, NOSIP, Nitric oxide synthase-interacting protein, E3 ubiquitin-protein ligase NOSIP, RING-type E3 ubiquitin transferase NOSIP, eNOS-interacting protein