Notum
Function
Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors.
Sequence Similarities
Belongs to the pectinacetylesterase family. Notum subfamily.
Tissue Specificity
Widely expressed. Expressed in lung, ovary, kidney, liver and brain. Not detected in thymus, heart, spleen, stomach, skeletal muscle and bone marrow.
Cellular localization
- Secreted
Alternative names
Palmitoleoyl-protein carboxylesterase NOTUM