NOTUM
Function
Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175).
Sequence Similarities
Belongs to the pectinacetylesterase family. Notum subfamily.
Tissue Specificity
Rarely expressed in adult normal tissues.
Cellular localization
- Secreted
Alternative names
OK/SW-CL.30, NOTUM, Palmitoleoyl-protein carboxylesterase NOTUM, hNOTUM