Nox1
Function
Isoform 1
NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor.
Isoform 2
NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor.
Post-translational modifications
Phosphorylation at Thr-457 mediated by PKC/PRKBC positively regulates its interaction with NOXA1 and enzyme activity.
Tissue Specificity
Isoform 2
Expressed in colon and vascular smooth muscle cells (VSMC).
Cellular localization
- Cell projection
- Invadopodium membrane
- Multi-pass membrane protein
- Cell membrane
- Multi-pass membrane protein
Alternative names
NADPH oxidase 1, NOX-1, Nox1