NOXA1
Developmental stage
Expressed in fetal kidney.
Domain
The SH3 domain mediates interaction with NOXO1 and NCF1 and has autoregulatory function.
The TPR repeats mediate interaction with RAC1.
Function
Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.
Post-translational modifications
Interaction with YWHAZ depends on phosphorylation by PKA.
Sequence Similarities
Belongs to the NCF2/NOXA1 family.
Tissue Specificity
Widely expressed. Detected in pancreas, liver, kidney, spleen, prostate, small intestine and colon.
Cellular localization
- Cytoplasm
- Cell membrane
- Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.
Alternative names
P51NOX, NOXA1, NADPH oxidase activator 1, NOX activator 1, Antigen NY-CO-31, NCF2-like protein, P67phox-like factor, p51-nox