NPLOC4
Domain
Binds ubiquitinated proteins via its RanBP2-type zinc finger.
Function
The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (PubMed:26471729).
Pathway
Protein degradation; proteasomal ubiquitin-dependent pathway.
Sequence Similarities
Belongs to the NPL4 family.
Tissue Specificity
Expressed at highest levels in brain, heart, skeletal muscle, kidney and fetal liver.
Cellular localization
- Cytoplasm
- Cytosol
- Endoplasmic reticulum
- Nucleus
- Associated with the endoplasmic reticulum and nuclear.
Alternative names
KIAA1499, NPL4, NPLOC4, Nuclear protein localization protein 4 homolog, Protein NPL4