NPM2
Domain
The acidic tract A2 mediates histone binding.
Function
Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization.
Sequence Similarities
Belongs to the nucleoplasmin family.
Cellular localization
- Nucleus
- Found in the oocyte nucleus before nuclear membrane breakdown, after which it is redistributed to the cytoplasm.
Alternative names
Nucleoplasmin-2, NPM2