NPNT
Developmental stage
Expressed in fetal kidney, cochlea, eye, heart and lung.
Domain
The MAM domain is required for localization at the cell surface.
Function
Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity).
Sequence Similarities
Belongs to the nephronectin family.
Tissue Specificity
Expressed in kidney and lung and to a lower extent in brain, pregnant uterus, placenta, thyroid gland and blood vessels.
Cellular localization
- Secreted
- Extracellular space
- Extracellular matrix
- Trapped on the cell surface or in the extracellular matrix.
Alternative names
EGFL6L, POEM, UNQ295/PRO334, NPNT, Nephronectin, Preosteoblast EGF-like repeat protein with MAM domain, Protein EGFL6-like